The pregnane x receptor

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August undefined, 2024

Webb18 mars 2009 · Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. … WebbPregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating enzymes, and phase III …

Pregnane X receptor (PXR) - A contributor to the diabetes …

Webb10 jan. 2014 · Financial & competing interests disclosure. The authors wish to thank the British Heart Foundation (BS/02/002), the Wellcome Trust (074361/Z/04/Z) and Barts … WebbThe pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, … phone speaker argos

Nutritional calcium modulates colonic expression of vitamin D …

Webb12 maj 2024 · The nuclear pregnane X receptor protects against bilateral renal ischemia/reperfusion-induced acute kidney injury in mice. Response to comment on … http://www.chinjmap.com/ch/reader/create_pdf.aspx?file_no=231339&flag=1&journal_id=zgyx&year_id=2013 phone speaker check

Pregnane X Receptor (PXR) Polymorphisms and Cancer …

Targeting the pregnane X receptor using microbial metabolite …

WebbThe pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands ( Kretschmer and Baldwin, 2005 ). … Webb2 okt. 2024 · Nuclear receptors such as the Pregnane X Receptor (PXR) are known to be key regulators of ABC drug transporters such as Abcb1, Abcc2, Abcc3, and Abcg2 [ 25, 26, 27, 28 ]. It is well known that PXR is activated by endogenous steroidal hormones and their metabolites, the levels of which are dramatically elevated during pregnancy. phone speaker cleaning kitWebbWe studied in mice and human adenocarcinoma-derived Caco-2 cells the impact of low calcium on markers of inflammation (cyclooxygenase-2; COX-2), of detoxification (pregnane and xenobiotic receptor (PXR)/steroid and xenobiotic receptor (SXR), … phone spazzing out

"http://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh " - The pregnane x receptor

The pregnane x receptor

Pregnane X Receptor and the Gut-Liver Axis: A Recent Update

Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to … Webb30 juni 2024 · Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is …

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http://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh WebbAbstract Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear …

WebbFarnesoid X receptor (FXR), a member of the nuclear receptor superfamily that is mainly expressed in enterohepatic tissues, has been discovered as a crucial regulator for balancing liver inflammatory processes and metabolism [ 5, 6, 7] and thus has become a pharmacological target for liver disorders. WebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse …

Webb29 okt. 2013 · Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification … WebbPregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR’s regulation. Antineoplastic agents are of particular interest since cancer …

Webb1 feb. 2024 · The pregnane X receptor (PXR) is a nuclear receptor which regulates drug metabolizing enzymes (DMEs) by activation from endogenous, as well as exogenous, …

WebbBackground: The pregnane X receptor (PXR) is a nuclear receptor (NR) involved in the detoxification of xenobiotic compounds via upregulation of cytochrome P450 enzyme … how do you spell crackerWebb28 juni 2013 · Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug … how do you spell creatingWebb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to … how do you spell creepedWebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology has examined the potential for PXR to regulate hepatic apoA-I and HDL formation in response to bileacids.12 Wild-typemice,miceinwhichthePXRgenehad how do you spell creekWebb20 apr. 2024 · The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial … how do you spell creepyWebb10 mars 2024 · Cheng J, Krausz KW, Tanaka N, Gonzalez FJ (2012a) Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci … phone speaker boxWebb1 apr. 2024 · Background. The pregnane X receptor (PXR) is a xenobiotic sensing nuclear receptor that is activated by a diverse array of substances, including environmental … how do you spell creep