WebMar 1, 2024 · In response to ER stress, ATF6 is transported from the ER to the Golgi apparatus and cleaved into a transcriptionally active p50ATF6. p50ATF6 then combines with the promoter of ER stress response elements in the nucleus, and induces expression of ER stress-related genes such as those encoding C/EBP homologous protein (CHOP)/growth … WebNov 16, 2001 · ATF6 activating transcription factor 6 PERK PKR-like ER kinase BiP immunoglobulin-binding protein Alzheimer's disease is a progressive neurodegenerative disorder characterized pathologically by deposition of amyloid β-protein (Aβ), 1 formation of neurofibrillary tangles, and neuronal death in brain regions ( 1 ).
Mammalian transcription factor ATF6 is synthesized as a …
WebATF6 Antibody - N-terminal region (ARP31688_P050) Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. For short term use, store at 2 … Web(ERSE) through which p50ATF6 exerts its activity (9–12). In parallel with ATF6, ER stress-inducing agents activate the IRE1 / proteins (15, 16). IRE1 is a ubiquitously ex-pressed ER type I transmembrane protein containing both a serine/threonine kinase module and an endoribonuclease do-main in its cytosolic region (15). Upon UPR activation, IRE1 lrs chvaly ops
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WebThe role of the ATF6 branch in cancer has been poorly explored to date, although indirect evidence exists indicating that ATF6α is an important modulator of chronic ER stress. For … WebATF6 processing required the RxxL and asparagine/proline motifs, known requirements for S1P and S2P processing, respectively [7]. Cells lacking S2P failed to induce GRP78, an ATF6 target, in response to ER stress [7]. ATF6 is a membrane-bound transcription factor that activates genes in the endoplasmic reticulum (ER) stress response [7]. lr scholars