WebDec 1, 2024 · Joubert syndrome (JBTS) is the archetypal ciliopathy caused by mutation of genes encoding ciliary proteins leading to multi-system phenotypes, including a cerebello-retinal-renal syndrome. JBTS is genetically heterogeneous, however mutations in CEP290 are a common underlying cause. WebFeb 23, 2024 · The Syracuse University Human Research Protections Program’s primary mission is the protection of individuals who are the subjects of research. Syracuse University is committed to follow the ethical standards described in the Belmont Report, and all applicable federal, state and local regulations and university policies and procedures. The ...
Rescue of CEP290 mutant cilia length defects in hURECs using ...
WebAn IRB is a committee within a university or other organization receiving federal funds to conduct research that reviews research proposals. The IRB reviews the proposals before a project is submitted to a funding agency to determine if the research project follows the ethical principles and federal regulations for the protection of human subjects. WebConversely, treatment of wild-type hURECs with the Hh antagonist HPI-4 replicated the abnormally long ciliary pheno- type, with increased tortuosity seen in 3 out of 10 cilia imaged using SEM. truth to power lyrics
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