WebMar 28, 2024 · But, HMMR is an intracellular, microtubule-associated, spindle assembly factor that localizes protein complexes to augment the activities of mitotic kinases, like polo-like kinase 1 and Aurora kinase A, and control dynein and kinesin motor activities. Expression of HMMR is elevated in cells prior to and during mitosis and tissues with ... Webthe synthesis or assembly of axonemes, dyneins, radial spokes or other similar structures. Dynein axonemal assembly factor 1 (DNAAF1) primarily affects the preassembly of the inner (IDA) and outer (ODA) dynein arms, which are multisubunit ATPase complexes (6). Mutations in DNAAF1 have been shown to cause
Dynein - an overview ScienceDirect Topics
WebJul 7, 2024 · Endogenously GFP-tagged PCNT forms dynamic aliphatic alcohol-sensitive pericentrosomal granules during late G2/early M phases. To study full-length PCNT at endogenous levels in cells, we used CRISPR technology (Lin et al., 2014a; Zhang et al., 2024) to insert super-folder GFP sequence into the 5′ end of the PCNT locus in hTERT … WebIn two of the seven patients with PCD, four novel dynein axonemal assembly factor 1 (DNAAF1) mutations were identified (NM_178452.6:c.3G>A, c.124+1G>C, c.509delG and c.943A>T) in three alleles. Both of these patients had long‑standing infertility. Their chest computed tomography results showed bronchiectasis, lung infections and situs ... circuit breakers riverside
ZFIN Gene: dnaaf1
WebMar 1, 2024 · Figure 1. Organization of axonemal dynein motors. (A) Linear map of a generic ∼4500-residue dynein heavy chain.The amino-terminal region contains two conserved segments found in nearly all these motors: DHC_N1 is involved in heavy-chain assembly, whereas DHC_N2 represents the linker that traverses the plane of the AAA … Webdynein axonemal assembly factor 1 Symbol dnaaf1 Nomenclature History Previous Names. loc123872 ; lrrc50; switch hitter ; swt ; unm tm317b; zgc:56169; Type protein_coding_gene Location Chr: 7 Mapping Details/Browsers Description Enables dynein complex binding activity. Involved in cilium assembly. ... WebRemoval of the centrosomal protein 110 (CP110) from the distal end of the mother centriole initiates the ciliary assembly. The work from Lee et al. demonstrated the differential role of the DAP, sodium channel and clathrin linker 1 (Sclt1) in ciliogenesis during embryonic fore- and hindlimb development in novel Sclt1 mutant mice. Sclt1 ... circuit breakers s01