WebAug 31, 2016 · The CTCF-only enrichment is characteristic for evolutionary old and inactive repeat classes, while BORIS and CTCF co-binding predominately occurs at … WebDec 5, 2024 · Analysis of CTCF and BORIS binding to repetitive elements also revealed striking distinctions between repeat-contained CTCF-only, CTCF&BORIS, and BORIS-only sites. 29 CTCF-only sites were enriched in evolutionarily ancient and inactive types of repeats, while CTCF&BORIS sites were mainly located in uncharacterized tandem …
CTCF: a Swiss-army knife for genome organization and
WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is known that shared and unique zinc finger sequences in CTCF and … WebCTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites … dundee things for kids
Victor Lobanenkov - Chief, Molecular Pathology …
WebApr 15, 2016 · The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin complex, make physical contacts that create large loop domains. Additional contacts between loci within those domains, often also mediated by CTCF, tend to be … WebATCF. Automated Tropical Cyclone Forecast (meteorology) ATCF. air traffic control facility. ATCF. Aero Touring Club de France. ATCF. Austrian Ticacat Fancy (Austrian Cat Club) … WebMay 6, 2013 · CTCF has it all. The transcription factor binds to tens of thousands of genomic sites, some tissue-specific, others ultra-conserved. It can act as a transcriptional activator, repressor and insulator, and it can pause transcription. CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. dundee tmas form