Cisplatin coordination complex
WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to … WebSep 12, 2024 · The platinum coordination complexes are a group of antineoplastic agents that are usually classified as alkylating agents, but which have distinctive features. Their anticancer activity appears to relate to the cross linking of DNA molecules in a fashion similar to standard alkylating agents.
Cisplatin coordination complex
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Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side … See more Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some See more Cisplatin is the square planar coordination complex cis-[Pt(NH3)2Cl2]. The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic … See more Syntheses of cisplatin start from potassium tetrachloroplatinate. Several procedures are available. One obstacle is the facile formation of Magnus's green salt (MGS), which has the same empirical formula as cisplatin. The traditional way to avoid MGS involves the … See more Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical … See more Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water … See more The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's … See more Cisplatin has been studied with Auger therapy to increase the therapeutic effects of cisplatin, without increasing normal tissue toxicities. See more WebOccasionally a 4-co-ordinated complex turns out to be square planar. There's no easy way of predicting that this is going to happen. The only one you might possibly come across at this level is cisplatin which is used …
WebCisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to bind to a guanine base on DNA. This property is …
WebNov 13, 2014 · The anticancer activity of this complex was screened against a panel of cancer cell lines. Remarkably, it exhibited IC50 values that were an order of magnitude lower than those of cisplatin. This complex also displayed potencies superior to those of cisplatin against 3D tumor spheroids. Web2 hours ago · Pivovarova and colleagues designed and evaluated copper coordination compounds containing thiazole-based derivatives. In the proposed series, two copper complexes exhibited cytotoxic effects on breast cancer cells with selectivity towards tumourigenic cells over healthy ones, definitively proving the efficacy of the proposed …
WebThe additional coordination positions offer the ability to design combinatorial therapies in a single complex, which is potentially more effective than the precursor platinum(II) complex. Specifically, platinum(IV) complexes are proposed to be stable in the bloodstream due to their low spin d 6 electronic configuration [ 32 ].
As metals only exist in solution as coordination complexes, it follows then that this class of compounds is useful in a wide variety of ways. In bioinorganic chemistry and bioorganometallic chemistry, coordination complexes serve either structural or catalytic functions. An estimated 30% of proteins contain metal ions. Examples include the intensely colored vitamin B12, the heme group in hemoglobin, the cytochromes, the chl… how is artificial vanilla flavoring madeWebConsidering the strong coordination capacity of copper, a variety of organic ligands, especially carboxyl-modified organic ligands, can be used to synthesize Cu-MOF through coordination reaction with copper. ... Copper complexes as anticancer agents. Cisplatin is a milestone in the field of metal complexes for cancer treatment, but because of ... high keratinWebcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells cis-Diamminedichloroplatinum(II): effects of a representative metal … high keppra blood levelWebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. high kelling caravan parkWebDec 8, 2024 · Abstract Phenanthriplatin is a new monofunctional platinum (II) complex that binds only one strand of DNA and acts by blocking gene transcription, but its effect on gene regulation has not been characterized relative to the … how is art therapy usedWebStructure of cisplatin, an example of a molecule with the square planar coordination geometry. The square planar molecular geometry in chemistry describes the stereochemistry (spatial arrangement of atoms) that is adopted by certain chemical compounds. As the name suggests, molecules of this geometry have their atoms … high keratin foodsWebMay 15, 2016 · Here, the available high resolution molecular structures for protein derivatives of cisplatin are systematically analyzed and discussed. In total, more than 40 distinct structures will be considered, as reported in Table 1. high kensington